Active curation · 120 indexed studies

Dehydration, Fibromyalgia
and Cognitive Function —
evidence with rigor.

Systematic curation of the intersection between dehydration, fibromyalgia and cognitive function — for physicians who need rigorous evidence and patients who need clear answers.

Hydration + Cognition Fibromyalgia + Fibrofog Central Sensitization
120 Indexed Articles (PubMed)
3 Curated thematic areas
GRADE Classified evidence strength
100% Open methodology · PICO
The three axes of the triad

One platform. Three bodies of evidence.
One single unifying hypothesis.

Each axis is a PubMed query structured by PICO, with classified evidence strength and dual summaries — for the clinician and for the patient.

Axis 01

Dehydration & Cognition

Impact of hydration status on attention, working memory and processing speed. Includes studies with subclinical deficits from 1% of body weight loss.

Desidratação + Cognição
Axis 02

Fibromyalgia & Fibrofog

Subjective and objective cognitive dysfunction in fibromyalgia: deficits in executive function, sustained attention and processing speed documented in adult patients.

Fibromialgia + Cognição
Axis 03

Hydration, Pain & Sensitization

Pain modulation by hydration status via central sensitization. Studies on nociceptive amplification, sleep and fluid intake as a bidirectional cycle in chronic pain.

Hidratação + Dor + Sensibilização
G1 Hypothesis

A vicious cycle
of four stages.

DFFCO's central hypothesis postulates that subclinical hypohydration amplifies pain via central sensitization, deteriorates sleep and further reduces fluid intake — closing the cycle that sustains fibrofog.

Hipótese pré-registrada · OSF · Atualização contínua

1 Subclinical hypohydration (elevated plasma osmolality)
2 Pain amplification via central sensitization
3 Sleep deterioration & REM fragmentation
4 Reduced fluid intake → worsening of fibrofog
Featured study

The strongest evidence of the intersection,
summarized for both sides.

High evidence Meta-analysis Axis 01 · Hydration + Cognition 2018

Dehydration impairs cognitive performance: A meta-analysis

Wittbrodt, M. T., & Millard-Stafford, M.

For the clinician: Reduction of 13.4% in working memory and 11.8% in reaction time with 2% body dehydration (n = 33 studies, 413 participants; I² = 32%).

For the person who feels it: When you become dehydrated, even a little, your memory and attention deteriorate measurably — it's not \"in your head\", it's in the data.
PMID: 29933347 · DOI: 10.1249/MSS.0000000000001682
Methodology

How the repository lives.

Each study goes through four curation stages — from which we publish every decision, query and criterion.

1

PICO-structured query

Population, Intervention, Comparator and Outcome translated into MeSH terms and text words with auditable boolean operators.

2

Screening & Curation

Pre-declared inclusion criteria. Each article is manually classified by study type, evidence strength and clinical relevance.

3

Strength classification

Adapted GRADE: High, Moderate, Low. Risk of bias assessed with RoB 2 (RCTs) and ROBINS-I (observational).

4

Dual summary

Each article receives a technical summary for the clinician and a plain-language summary for the patient — reviewed separately.

pubmed-query.txt · Eixo 01
("Dehydration"[Mesh] OR "hypohydration"[tiab])
AND
("Cognition"[Mesh] OR "working memory"[tiab] OR "attention"[tiab])
AND
("2010"[PDat] : "2026"[PDat])
AND humans[Filter]
PICO methodology · pre-declared criteria ● Active curation
Who DFFCO is for

Two languages, simultaneously.
Same evidence, without distortion.

For physicians & researchers

Systematic curation that saves bibliographic search time, with rigorous classification.

  • PubMed queries structured by PICO, exportable in TXT/RIS
  • GRADE evidence strength + risk of bias per study
  • Continuous update via E-utilities — without manual revisions
  • Pre-formatted citations (Vancouver, ABNT, BibTeX)

For those living with fibromyalgia

Science already has some answers about what you feel. Here they are, without jargon.

  • Summaries in clear language, without losing rigor
  • Glossary for terms like \"fibrofog\" and \"central sensitization\"
  • What you can take to talk with your doctor
  • No promise of a cure — only what the studies show
The origin of DFFCO

This platform was not born in a laboratory.
It was born at home.

"My fiancée has fibromyalgia, cognitive deficit and doesn't drink water. The question — is there a relationship between all this? — became this platform."

DFFCO is an evidence platform, but the heart is a real story. That's why we never talk about patients — we talk with them. And that's why each study passes through the same filter: would this help the person we love understand better what they feel?